SDRP Journal of Food Science & Technology

Prenatal Developmental Toxicity Study of HEA-enriched Cordyceps Cicadae Mycelia in Sprague-Dawley Rats

Co-Authors

First Author: I-Chen Li
Co-Authors: Hsu JH; Lin TW; Lin WH and Chen CC

Citation

I-Chen Li, Hsu JH; Lin TW; Lin WH and Chen CC, Prenatal Developmental Toxicity Study of HEA-enriched Cordyceps Cicadae Mycelia in Sprague-Dawley Rats(2017)SDRP Journal of Food Science & Technology 2(1)

Abstract

Background:

Cordyceps cicadae (C. cicadae) has been used in traditional medicine and is presently being developed for therapeutic purposes and dietary supplements. One of its effective bioactive ingredients is N6-(2-hydroxyethyl) adenosine (HEA), which can exert an analgesic effect by inhibiting neurotransmitter release and can be used to ameliorate moderate to severe pain, including cancer pain. Although there have been extensive studies confirming its safety, the embryo-fetal development toxicity of HEA-enriched C. cicadae mycelia has not been evaluated.

Methods:

This study was to describe the potential adverse effects of orally administered HEA-enriched C. cicadae mycelia on fertility and early embryonic development to implantation in Sprague-Dawley rats at doses of 500, 1,000, and 1,500 mg/kg.

Results:

No external, visceral as well as skeletal abnormalities were noted among all groups. There were no statistically significant differences in the number of fetuses, corpora lutea, implantation sites, embryo resorptions, stillbirths, and post-implantation between all dosing groups. Moreover, there was no embryo-fetal developmental toxicity observed.

Conclusion:

The no-observed-adverse-effect level (NOAEL) of HEA-enriched C. cicadae mycelia was considered to be greater than 1500 mg/kg. As there was no evidence of teratogenic effect, HEA-enriched C. cicadae mycelia were therefore not considered as a potent embryotoxin in rats.

Keywords:

N6-(2-hydroxyethyl) adenosine; traditional medicine; teratogenicity; no-observed-adverse-effect level.

 

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