Journal of Food Science & Technology

ISSN: 2472-6419

Impact Factor: 1.265

VOLUME: 5 ISSUE: 1

EFFECT OF ARTOCARPUS ALTILIS LEAF POWDER SUPPLEMENTED DIET ON KEY ENZYMES RELEVANT TO ACUTE TYPE-2 DIABETES IN ALLOXAN INDUCED DIABETIC RATS.


Abstract

Abstract The anti-diabetic effects of Artocarpus altilis (A. altilis) leaf powder was investigated by evaluating the ameliorating effect on glucose concentration and its inhibitory properties of A. altilis leaf powder towards carbohydrate hydrolyzing enzymes, i.e., α-glucosidase, α-amylase and glucose 6 phosphate dehydrogenase. Forty (40) adult albino Wistar rats (male) were used for the study. The animals were divided into five groups of eight rats each. Hyperglycemia was induced in the rats using alloxan. A diet was formulated using 5% A. altilis leaf powder. The animals were fed with the formulated diet for four (4) weeks; blood samples were collected from the animals and analyzed for glucose levels using Accu – Check glucometer. The data were compared statistically using analysis of variance (ANOVA). There was a remarkable decrease in blood glucose in both the treated and the pre-treated group. The supplementary diet showed a significant decrease (P≤ 0.05) alpha amylase, alpha glucosidase and G6PD inhibitory activity. The decrease in the blood glucose level of the rats following the administration of the supplemented diet suggests that the plant leaf possesses anti-diabetic, anti-hyperglycemic and hypoglycemic effects on alloxan induced diabetic rats. The presence of phytochemicals, vitamins, and other nutrients such as proteins, lipids, carbohydrates, ash, and other components in the leaf must have acted synergistically to potentiate the anti-diabetic role of the plant leaf. Keyword: Diabetes, Artocarpus altilis, Enzymes

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