[Treatment, clinical course, and cross-sectoral information transmission in patients with acute-on-chronic kidney injury].


Abteilung für Kardiologie, Immanuel Klinikum Bernau Herzzentrum Brandenburg, Ladeburger Str. 17, 16321, Bernau, Deutschland. [Email]


BACKGROUND : Delayed diagnosis and undertherapy of acute-on-chronic kidney injury (AKI-on-CKD) may trigger multiple organ injury and worsen clinical outcome.
OBJECTIVE : This study focused on description of in-hospital care and cross-sectoral information transmission of patients with AKI-on-CKD including subgroup analyses (under surgical vs. non-surgical and nephrology vs. non-nephrology care).
METHODS : At a university clinic, we analysed clinical measures and documentation in patients with AKI-on-CKD. Cox regression was performed to identify independent risk factors for in-hospital-mortality and 180-day mortality.
RESULTS : In 38 (25.3%) of 150 patients, progressing AKI-on-CKD was found. Nineteen patients (12.7%) received acute dialysis. Thirty patients (20.0%) died in hospital. Systemic hypotension (n = 76, 50.7%) and nephrotoxins (n = 26, 17.3%), both considered as causes for AKI-on-CKD, were treated in 36.8 and 19.2%, respectively, of affected patients. Fluid balance was documented in one third of patients. Nephrology referral was requested in 38 (25.3%) of patients (median 24.0 h after AKI-on-CKD start). Acute renal complications (n = 74, 49.3%) were an independent risk factor for in-hospital mortality (ExpB 6.5, p = 0.022) or 180-day mortality (ExpB 3.3, p = 0.034). Rarely, outpatient physicians were informed about AKI-on-CKD (n = 42, 28.0%) or renal function follow-up was recommended (n = 14, 11.7% of surviving patients).
CONCLUSIONS : Care gaps in therapy and cross-sectoral information transmission in patients with AKI-on-CKD were identified.


Acute renal failure,Care bundle,Chronic kidney disease,Discharge letter,Undertherapy,

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