Aberrant activity in conceptual networks underlies N400 deficits and unusual thoughts in schizophrenia.

Affiliation

San Francisco VA Medical Center, 4150 Clement St, San Francisco, CA 94110, United States; University of California, Department of Psychiatry, 401 Parnassus Avenue, San Francisco, CA 94143, United States. Electronic address: [Email]

Abstract

The N400 event-related potential (ERP) is triggered by meaningful stimuli that are incongruous, or unmatched, with their semantic context. Functional magnetic resonance imaging (fMRI) studies have identified brain regions activated by semantic incongruity, but their precise links to the N400 ERP are unclear. In schizophrenia (SZ), N400 amplitude reduction is thought to reflect overly broad associations in semantic networks, but the abnormalities in brain networks underlying deficient N400 remain unknown. We utilized joint independent component analysis (JICA) to link temporal patterns in ERPs to neuroanatomical patterns from fMRI and investigate relationships between N400 amplitude and neuroanatomical activation in SZ patients and healthy controls (HC).

Keywords

Joint-ICA,N400,Schizophrenia,Semantic priming,fMRI,

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