An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence.

Affiliation

Dhimolea E(1), de Matos Simoes R(2), Kansara D(3), Al'Khafaji A(4), Bouyssou J(5), Weng X(6), Sharma S(6), Raja J(6), Awate P(6), Shirasaki R(2), Tang H(2), Glassner BJ(2), Liu Z(7), Gao D(8), Bryan J(4), Bender S(4), Roth J(4), Scheffer M(2), Jeselsohn R(9), Gray NS(9), Georgakoudi I(7), Vazquez F(4), Tsherniak A(4), Chen Y(8), Welm A(10), Duy C(11), Melnick A(12), Bartholdy B(13), Brown M(9), Culhane AC(14), Mitsiades CS(15).
Author information:
(1)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ludwig Center at Harvard, Boston, MA, USA. Electronic address: [Email]
(2)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ludwig Center at Harvard, Boston, MA, USA.
(3)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Ludwig Center at Harvard, Boston, MA, USA.
(4)Broad Institute of MIT and Harvard, Cambridge, MA, USA.
(5)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
(6)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA.
(7)Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
(8)Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
(9)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
(10)Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
(11)Department of Medicine, Weill Cornell Medicine, New York, NY, USA; Cancer Signaling and Epigenetics Program, Institute for Cancer Research, Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
(12)Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
(13)Albert Einstein College of Medicine, Bronx, NY 10461, USA.
(14)Department of Data Sciences, Dana-Farber Cancer Institute & Harvard T.H. Chan School of Public Health, Boston, MA, USA.
(15)Department of Medical Oncology, Dana-Farber Cancer Institute Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ludwig Center at Harvard, Boston, MA, USA. Electronic address: [Email]

Abstract

Comment in Cancer Cell. 2021 Feb 8;39(2):142-144.