Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning.


BioInnovation Institute, Ole Maaløes Vej 3, DK2200 Copenhagen N, Denmark; Department of Biology and Biological Engineering, Chalmers University of Technology, SE41296 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK2800 Kgs. Lyngby, Denmark. Electronic address: [Email]


In this issue of Cell, Yang, Wright et al. describe a machine learning approach that that can provide mechanistic insight from chemical screens. They use this approach to uncover how the nutritional availability for Escherichia coli impacts lethality toward three widely used antibiotics.