Antitumor effect of a dual cancer-specific oncolytic adenovirus on prostate cancer PC-3 cells.

Affiliation

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P. R. China; Department of Urology Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P. R. China. Electronic address: [Email]

Abstract

Apoptin can specifically kill cancer cells but has no toxicity to normal cells. Human telomerase reverse transcriptase (hTERT) acts as a tumor-specific promoter, triggering certain genes to replicate or express only in tumor cells, conferring specific replication and killing abilities. This study aimed to investigate the anticancer potential of the recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in prostate cancer.

Keywords

Apoptin,PC-3-luc cells,Recombinant adenovirus,hTERT,

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