Asperpenes D and E from the fungus Aspergillus sp. SCS-KFD66 isolated from a bivalve mollusk, Sanguinolaria chinensis.


An CL(1)(2), Kong FD(1), Li Y(3), Ma QY(1), Xie QY(1), Yuan JZ(1), Zhou LM(1), Dai HF(1), Yu ZF(2), Zhao YX(1).
Author information:
(1)Haina Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
(2)College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
(3)Department of Computer Teaching and Research, Heze Jia Zheng Vocational College, Heze 274000, China.


Two new compounds named asperpenes D (1) and E (2) were isolated from the marine-derived fungus Aspergillus sp. SCS-KFD66. Their structures were determined on the basis of spectroscopic methods. Compound 2 represents the first natural product bearing a 2-substituted-5-oxo-4-phenyl-2,5-dihydrofuran-3-carboxylic acid skeleton. All the compounds were tested for enzyme inhibitory activity against AChE and α-glucosidase and DPPH radical scavenging activity, respectively. [Formula: see text].