Associations of vitamin D binding protein variants with the vitamin D-induced increase in serum 25-hydroxyvitamin D.


Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [Email]


Vitamin D deficiency is a global problem that may be improved by vitamin D supplementation; however, the individual's response to the intervention varies. We aimed to investigate possible genetic factors that may modify the impact of environmental exposure on vitamin D status. The candidate gene variant we investigated was the Gc gene-rs4588 polymorphism at the vitamin D receptor (DBP) locus.


Gc gene,Supplementation,Total 25(OH) D,rs4588,