Attenuation of retinal nerve fibre layer in people with epilepsy receiving valproate.


Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address: [Email]


Valproate (VPA) is one of the most frequently used anti-epileptic drugs (AEDs) worldwide. Its effects in decreasing the retinal nerve fibre layer (RNFL) thickness remain debatable. We aimed to evaluate the effect of VPA usage on the RNFL in comparison with other AEDs and no AED usage in people with epilepsy (PWE).


Optical coherence tomography,Patient with epilepsy,Retinal nerve fiber layer,Valproate,