Bioactive Compounds Isolated from Marine-Derived Microbes in China: 2009-2018.


School of Pharmaceutical Science and Technology, Health Science Platform, Tianjin University, 92 Weijin Road, Tianjin 300072, China. [Email]


This review outlines the research that was carried out regarding the isolation of bioactive compounds from marine-derived bacteria and fungi by China-based research groups from 2009-2018, with 897 publications being surveyed. Endophytic organisms featured heavily, with endophytes from mangroves, marine invertebrates, and marine algae making up more than 60% of the microbial strains investigated. There was also a strong focus on fungi as a source of active compounds, with 80% of publications focusing on this area. The rapid increase in the number of publications in the field is perhaps most notable, which have increased more than sevenfold over the past decade, and suggests that China-based researchers will play a major role in marine microbial natural products drug discovery in years to come.


drug discovery,endophytic fungi,marine-derived microbes,

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