Bioluminescence Imaging of Transplanted Mesenchymal Stem Cells by Overexpression of Hepatocyte Nuclear Factor4α: Tracking Biodistribution and Survival.


Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [Email]


The purposes of this study were to construct immortalized human bone marrow mesenchymal stem cells (UE7T-13) with overexpression of the hepatocyte nuclear factor4α (hHNF4α) and luciferase2-mKate2 dual-fusion reporter gene, further investigate their impact on treating acute liver injury (ALI) in rats, and track their biodistribution and survival by bioluminescence imaging (BLI).


Bioluminescence imaging,Hepatocyte nuclear factor4α,Hepatocyte-like cell,Mesenchymal stem cell,

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