Collaborators: Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley KA, Parsons MT, Fortuno C, Wang Q, Bolla MK, Dennis J, Keeman R, Alonso MR, Álvarez N, Herraez B, Fernandez V, Núñez-Torres R, Osorio A, Valchich J, Li M, Törngren T, Harrington PA, Baynes C, Conroy DM, Decker B, Fachal L, Mavaddat N, Ahearn T, Aittomäki K, Antonenkova NN, Arnold N, Arveux P, Ausems MGEM, Auvinen P, Becher H, Beckmann MW, Behrens S, Bermisheva M, Białkowska K, Blomqvist C, Bogdanova NV, Bogdanova-Markov N, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Bremer M, Briceno I, Brüning T, Burwinkel B, Cameron DA, Camp NJ, Campbell A, Carracedo A, Castelao JE, Cessna MH, Chanock SJ, Christiansen H, Collée JM, Cordina-Duverger E, Cornelissen S, Czene K, Dörk T, Ekici AB, Engel C, Eriksson M, Fasching PA, Figueroa J, Flyger H, Försti A, Gabrielson M, Gago-Dominguez M, Georgoulias V, Gil F, Giles GG, Glendon G, Gómez Garcia EB, Grenaker Alnæs GI, Guénel P, Hadjisavvas A, Haeberle L, Hahnen E, Hall P, Hamann U, Harkness EF, Hartikainen JM, Hartman M, He W, Heemskerk-Gerritsen BAM, Hillemanns P, Hogervorst FBL, Hollestelle A, Ho WK, Hooning MJ, Howell A, Humphreys K, Idris F, Jakubowska A, Jung A, Kapoor PM, Kerin MJ, Khusnutdinova E, Kim SW, Ko YD, Kosma VM, Kristensen VN, Kyriacou K, Lakeman IMM, Lee JW, Lee MH, Li J, Lindblom A, Lo WY, Loizidou MA, Lophatananon A, Lubiński J, MacInnis RJ, Madsen MJ, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Maurer T, Mavroudis D, McLean C, Meindl A, Mensenkamp AR, Michailidou K, Miller N, Taib NAM, Muir K, Mulligan AM, Nevanlinna H, Newman WG, Nordestgaard BG, Ng PS, Oosterwijk JC, Park SK, Park-Simon TW, Perez JIA, Peterlongo P, Porteous DJ, Prajzendanc K, Prokofyeva D, Radice P, Rashid MU, Rhenius V, Rookus MA, Rüdiger T, Saloustros E, Sawyer EJ, Schmutzler RK, Schneeweiss A, Schürmann P, Shah M, Sohn C, Southey MC, Surowy H, Suvanto M, Thanasitthichai S, Tomlinson I, Torres D, Truong T, Tzardi M, Valova Y, van Asperen CJ, Van Dam RM, van den Ouweland AMW, van der Kolk LE, van Veen EM, Wendt C, Williams JA, Yang XR, Yoon SY, Zamora MP, Evans DG, de la Hoya M, Simard J, Antoniou AC, Borg Å, Andrulis IL, Chang-Claude J, García-Closas M, Chenevix-Trench G, Milne RL, Pharoah PDP, Schmidt MK, Spurdle AB, Vreeswijk MPG, Benitez J, Dunning AM, Kvist A, Teo SH, Devilee P, Easton DF. Author information:
(1)The authors' affiliations are as follows: the Centre for Cancer Genetic
Epidemiology, Departments of Public Health and Primary Care (L.D., S. Carvalho,
J.A., K.A.P., Q.W., M.K.B., J.D., B.D., N. Mavaddat, K. Michailidou, A.C.A.,
P.D.P.P., D.F.E.) and Oncology (C.L., P.A.H., C. Baynes, D.M.C., L.F., V.R., M.
Shah, P.D.P.P., A.M.D., D.F.E.), University of Cambridge, Cambridge, the Centre
for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular
Medicine (A. Campbell, D.J.P.), and the Centre for Cognitive Ageing and
Cognitive Epidemiology, Department of Psychology (D.J.P.), University of
Edinburgh, the Cancer Research UK Edinburgh Centre (D.A.C., J.F.), and the Usher
Institute of Population Health Sciences and Informatics, University of Edinburgh
Medical School (A. Campbell, J.F.), Edinburgh, the Divisions of Informatics,
Imaging, and Data Sciences (E.F.H.), Cancer Sciences (A. Howell), Population
Health, Health Services Research, and Primary Care (A. Lophatananon, K. Muir),
and Evolution and Genomic Sciences, School of Biological Sciences (W.G.N.,
E.M.V., D.G.E.), University of Manchester, the NIHR Manchester Biomedical
Research Unit (E.F.H.) and the Nightingale Breast Screening Centre, Wythenshawe
Hospital (E.F.H., H.I.), Academic Health Science Centre and North West Genomics
Laboratory Hub, and the Manchester Centre for Genomic Medicine, St. Mary's
Hospital, Manchester University NHS Foundation Trust (W.G.N., E.M.V., D.G.E.),
Manchester, the School of Cancer and Pharmaceutical Sciences, Comprehensive
Cancer Centre, Guy's Campus, King's College London, London (E.J.S.), the
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham
(I.T.), and the Wellcome Trust Centre for Human Genetics and Oxford NIHR
Biomedical Research Centre, University of Oxford, Oxford (I.T.) - all in the
United Kingdom; the Human Genotyping-CEGEN Unit, Human Cancer Genetic Program
(A.G.-N., M.R.A., N.Á., B.H., R.N.-T.), and the Human Genetics Group (V.F.,
A.O., J.B.), Spanish National Cancer Research Center, Centro de Investigación en
Red de Enfermedades Raras (A.O., J.B.), Servicio de Oncología Médica, Hospital
Universitario La Paz (M.P.Z.), and Molecular Oncology Laboratory, Hospital
Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico
San Carlos (M. de la Hoya), Madrid, the Genomic Medicine Group, Galician
Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago
de Compostela, Complejo Hospitalario Universitario de Santiago (A. Carracedo,
M.G.-D.), and Centro de Investigación en Red de Enfermedades Raras y Centro
Nacional de Genotipado, Universidad de Santiago de Compostela (A. Carracedo),
Santiago de Compostela, the Oncology and Genetics Unit, Instituto de
Investigacion Sanitaria Galicia Sur, Xerencia de Xestion Integrada de
Vigo-Servizo Galeo de Saúde, Vigo (J.E.C.), and Servicio de Cirugía General y
Especialidades, Hospital Monte Naranco, Oviedo (J.I.A.P.) - all in Spain; the
Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund
University, Lund (C. Wahlström, J.V., M.L., T. Törngren, Å.B., A.K.), the
Department of Oncology, Örebro University Hospital, Örebro (C. Blomqvist), and
the Departments of Medical Epidemiology and Biostatistics (K.C., M.E., M.G., P.
Hall, W.H., K.H.), Oncology, Södersjukhuset (P. Hall, S. Margolin), Molecular
Medicine and Surgery (A. Lindblom), and Clinical Science and Education,
Södersjukhuset (S. Margolin, C. Wendt), Karolinska Institutet, and the
Department of Clinical Genetics, Karolinska University Hospital (A. Lindblom),
Stockholm - all in Sweden; the Department of Genetics and Computational Biology,
QIMR Berghofer Medical Research Institute, Brisbane, QLD (M.T.P., C.F., G.C.-T.,
A.B.S.), the Cancer Epidemiology Division, Cancer Council Victoria (G.G.G.,
R.J.M., R.L.M.), the Centre for Epidemiology and Biostatistics, Melbourne School
of Population and Global Health (G.G.G., R.J.M., R.L.M.), and the Department of
Clinical Pathology (M.C.S.), University of Melbourne, Anatomical Pathology,
Alfred Hospital (C.M.), and the Cancer Epidemiology Division, Cancer Council
Victoria (M.C.S.), Melbourne, VIC, and Precision Medicine, School of Clinical
Sciences at Monash Health, Monash University, Clayton, VIC (G.G.G., M.C.S.,
R.L.M.) - all in Australia; the Division of Molecular Pathology (R.K., S.
Cornelissen, M.K.S.), Family Cancer Clinic (F.B.L.H., L.E.K.), Department of
Epidemiology (M.A.R.), and Division of Psychosocial Research and Epidemiology
(M.K.S.), the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital,
Amsterdam, Division Laboratories, Pharmacy and Biomedical Genetics, Department
of Genetics, University Medical Center, Utrecht (M.G.E.M.A.), the Department of
Clinical Genetics, Erasmus University Medical Center (J.M.C., A.M.W.O.), and the
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer
Institute (B.A.M.H.-G., A. Hollestelle, M.J.H.), Rotterdam, the Department of
Clinical Genetics, Maastricht University Medical Center, Maastricht (E.B.G.G.),
the Departments of Human Genetics (I.M.M.L., M.P.G.V., P.D.), Clinical Genetics
(C.J.A.), and Pathology (P.D.), Leiden University Medical Center, Leiden, the
Department of Human Genetics, Radboud University Medical Center, Nijmegen
(A.R.M.), and the Department of Genetics, University Medical Center Groningen,
University of Groningen, Groningen (J.C.O.) - all in the Netherlands; the Cancer
Genetics and Comparative Genomics Branch, National Human Genome Research
Institute (B.D.), and the Division of Cancer Epidemiology and Genetics, National
Cancer Institute (T.A., S.J.C., X.R.Y., M.G.-C.), National Institutes of Health,
Bethesda, MD; the Department of Pathology, Brigham and Women's Hospital, Harvard
Medical School (B.D.), and the Department of Nutrition, Harvard T.H. Chan School
of Public Health (R.M.V.D.), Boston; the Departments of Clinical Genetics
(K.A.), Oncology (C. Blomqvist), and Obstetrics and Gynecology (H.N., M.
Suvanto), Helsinki University Hospital, University of Helsinki, Helsinki, and
the Unit of Clinical Oncology, Kuopio University Hospital (P. Auvinen), the
Institute of Clinical Medicine, Oncology (P. Auvinen), the Translational Cancer
Research Area (J.M.H., V.-M.K., A. Mannermaa), and the Institute of Clinical
Medicine, Pathology, and Forensic Medicine (J.M.H., V.-M.K., A. Mannermaa),
University of Eastern Finland, and the Biobank of Eastern Finland, Kuopio
University Hospital (V.-M.K., A. Mannermaa), Kuopio - both in Finland; the N.N.
Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
(N.N.A., N.V.B.); the Department of Gynecology and Obstetrics and Institute of
Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus
Kiel, Christian-Albrechts University Kiel, Kiel (N.A.), the Institute of Medical
Biometry and Epidemiology (H. Becher) and Cancer Epidemiology Group (T.M.,
J.C.-C.), University Cancer Center Hamburg, University Medical Center
Hamburg-Eppendorf, Hamburg, the Department of Gynecology and Obstetrics (M.W.B.,
P.A.F., L.H.) and Institute of Human Genetics (A.B.E.), University Hospital
Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive
Cancer Center Erlangen-European Metropolitan Region of Nuremberg, Erlangen, the
Division of Cancer Epidemiology (S.B., A. Jung, P.M.K., J.C.-C.), Molecular
Epidemiology Group, C080 (B. Burwinkel, H.S.), Division of Pediatric
Neurooncology (A.F.), and Molecular Genetics of Breast Cancer (U.H., M.M.,
M.U.R., D.T.), German Cancer Research Center, Molecular Biology of Breast
Cancer, University Women's Clinic Heidelberg, University of Heidelberg (B.
Burwinkel, A.S., H.S.), Hopp Children's Cancer Center (A.F.), Faculty of
Medicine, University of Heidelberg (P.M.K.), and National Center for Tumor
Diseases, University Hospital and German Cancer Research Center (A.S., C.S.),
Heidelberg, the Department of Radiation Oncology (N.V.B., M. Bremer, H.C.) and
the Gynecology Research Unit (N.V.B., T.D., P. Hillemanns, T.-W.P.-S., P.S.),
Hannover Medical School, Hannover, the Institute of Human Genetics, University
of Münster, Münster (N.B.-M.), Dr. Margarete Fischer-Bosch-Institute of Clinical
Pharmacology, Stuttgart (H. Brauch, W.-Y.L.), iFIT-Cluster of Excellence,
University of Tübingen, and the German Cancer Consortium, German Cancer Research
Center, Partner Site Tübingen (H. Brauch), and the University of Tübingen
(W.-Y.L.), Tübingen, Institute for Prevention and Occupational Medicine of the
German Social Accident Insurance, Institute of the Ruhr University Bochum,
Bochum (T.B.), Institute for Medical Informatics, Statistics, and Epidemiology,
University of Leipzig, Leipzig (C.E.), Center for Hereditary Breast and Ovarian
Cancer (E.H., R.K.S.) and Center for Integrated Oncology (E.H., R.K.S.), Faculty
of Medicine and University Hospital Cologne, University of Cologne, Cologne, the
Department of Internal Medicine, Evangelische Kliniken Bonn, Johanniter
Krankenhaus, Bonn (Y.-D.K.), the Department of Gynecology and Obstetrics,
University of Munich, Campus Großhadern, Munich (A. Meindl), and the Institute
of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe (T.R.) - all in Germany;
the Gynecological Cancer Registry, Centre Georges-François Leclerc, Dijon (P.
Arveux), and the Center for Research in Epidemiology and Population Health, Team
Exposome and Heredity, INSERM, University Paris-Saclay, Villejuif (E.C.-D.,
P.G., T. Truong) - both in France; the Institute of Biochemistry and Genetics,
Ufa Federal Research Center of the Russian Academy of Sciences (M. Bermisheva,
E.K.), the Department of Genetics and Fundamental Medicine, Bashkir State
University (E.K., D.P., Y.V.), and the Ufa Research Institute of Occupational
Health and Human Ecology (Y.V.), Ufa, Russia; the Department of Genetics and
Pathology (K.B., A. Jakubowska, J. Lubiński, K.P.) and the Independent
Laboratory of Molecular Biology and Genetic Diagnostics (A. Jakubowska),
Pomeranian Medical University, Szczecin, Poland; the Copenhagen General
Population Study, the Department of Clinical Biochemistry (S.E.B., B.G.N.), and
the Department of Breast Surgery (H.F.), Herlev and Gentofte Hospital,
Copenhagen University Hospital, Herlev, and the Faculty of Health and Medical
Sciences, University of Copenhagen, Copenhagen (S.E.B., B.G.N.) - both in
Denmark; the Division of Cancer Prevention and Genetics, European Institute of
Oncology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) (B.
Bonanni), the Unit of Medical Genetics, Department of Medical Oncology and
Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (S.
Manoukian), the Genome Diagnostics Program, FIRC Institute of Molecular Oncology
(P.P.), and the Unit of Molecular Bases of Genetic Risk and Genetic Testing,
Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (P.R.),
Milan; the Department of Cancer Genetics, Institute for Cancer Research, Oslo
University Hospital-Radiumhospitalet (A.-L.B.-D., G.I.G.A., V.N.K.), and the
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
(A.-L.B.-D., V.N.K.), Oslo; Medical Faculty, Universidad de La Sabana (I.B.),
and the Clinical Epidemiology and Biostatistics Department (F.G.) and Institute
of Human Genetics (D.T.), Pontificia Universidad Javeriana, Bogota, Colombia;
the Department of Internal Medicine and Huntsman Cancer Institute, University of
Utah (N.J.C., M.J.M., J.A.W.), and the Intermountain Healthcare Biorepository
and Department of Pathology, Intermountain Healthcare (M.H.C.), Salt Lake City;
the David Geffen School of Medicine, Department of Medicine Division of
Hematology and Oncology, University of California, Los Angeles (P.A.F.), and
Moores Cancer Center (M.G.-D., M.E.M.) and the Department of Family Medicine and
Public Health (M.E.M.), University of California San Diego, La Jolla; the
Departments of Medical Oncology (V.G., D.M.) and Pathology (M.T.), University
Hospital of Heraklion, Heraklion, and the Department of Oncology, University
Hospital of Larissa, Larissa (E.S.) - both in Greece; the Fred A. Litwin Center
for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai
Hospital (G.G., I.L.A.), the Departments of Laboratory Medicine and Pathobiology
(A.M.M.) and Molecular Genetics (I.L.A.), University of Toronto, and the
Laboratory Medicine Program, University Health Network (A.M.M.), Toronto, and
the Genomics Center, Centre Hospitalier Universitaire de Québec-Université Laval
Research Center, Québec City, QC (J.S.) - both in Canada; the Department of
Electron Microscopy and Molecular Pathology (A. Hadjisavvas, K.K., M.A.L.), the
Cyprus School of Molecular Medicine (A. Hadjisavvas, K.K., M.A.L., K.
Michailidou), and the Biostatistics Unit (K. Michailidou), Cyprus Institute of
Neurology and Genetics, Nicosia, Cyprus; the Saw Swee Hock School of Public
Health (M. Hartman, R.M.V.D.) and the Department of Medicine, Yong Loo Lin
School of Medicine (R.M.V.D.), National University of Singapore, the Department
of Surgery, National University Health System (M. Hartman, J. Li), and the Human
Genetics Division, Genome Institute of Singapore (J. Li), Singapore; the
Department of Mathematical Sciences, Faculty of Science and Engineering,
University of Nottingham Malaysia (W.K.H.), and the Breast Cancer Research
Programme, Cancer Research Malaysia (W.K.H., P.S.N., S.-Y.Y., S.H.T.), Selangor,
and the Breast Cancer Research Unit, Cancer Research Institute (N.A.M.T.), and
the Department of Surgery, Faculty of Medicine (N.A.M.T., P.S.N., S.H.T.),
University Malaya, Kuala Lumpur - both in Malaysia; Surgery, School of Medicine,
National University of Ireland, Galway (M.J.K., N. Miller); the Department of
Surgery, Daerim Saint Mary's Hospital (S.-W.K.), the Department of Surgery,
Ulsan University College of Medicine and Asan Medical Center (J.W.L.), the
Department of Surgery, Soonchunhyang University College of Medicine and
Soonchunhyang University Hospital (M.H.L.), Integrated Major in Innovative
Medical Science, Seoul National University College of Medicine (S.K.P.), and the
Cancer Research Institute, Seoul National University (S.K.P.), Seoul, South
Korea; the Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital
and Research Center, Lahore, Pakistan (M.U.R.); and the National Cancer
Institute, Ministry of Public Health, Nonthaburi, Thailand (S.T.).
