Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise.


McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Electronic address: [Email]


The N-end rule pathway mediates the degradation of proteins through their destabilizing amino-terminal residues. While previously implicated in apoptosis regulation, N-end rule degradation has now recently been shown to fine-tune pyroptotic cellular demise through the amino-terminal degradation of the inflammasome component NLRP1B.