Changes in antimicrobial resistance and outcomes of health care-associated infections.

Affiliation

Aydın M(1), Azak E(2), Bilgin H(3), Menekse S(4), Asan A(5), Mert HTE(6), Yulugkural Z(6), Altunal LN(7), Hatipoğlu ÇA(8), Tuncer Ertem G(8), Altunok ES(9), Demirkaya MH(10), Çeviker SA(11), Akgul F(12), Memis Z(13), Konya P(14), Azap A(15), Aydin G(15), Korkmaz D(16), Karakoç ZÇ(17), Yapar D(18), Karakecili F(19), Gunal O(20), Keske S(21), Kapmaz M(21), Kader C(22), Demirel A(23), Ergönül Ö(21).
Author information:
(1)Department of Infectious Diseases and Clinical Microbiology, Umraniye Research and Training Hospital University of Health Science, Elmalıkent, Adem Yavuz Cd., 34764, Ümraniye/İstanbul, Turkey. [Email]
(2)Department of Infectious Diseases and Clinical Microbiology, School of Medicine, University of Kocaeli, Kocaeli, Turkey.
(3)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Marmara University, Istanbul, Turkey.
(4)Department of Infectious Diseases and Clinical Microbiology, Kartal Koşuyolu Research and Training Hospital, Istanbul, Turkey.
(5)Department of Infectious Diseases and Clinical Microbiology, University of Health Science, Bursa, Turkey.
(6)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trakya University, Edirne, Turkey.
(7)Department of Infectious Diseases and Clinical Microbiology, Umraniye Research and Training Hospital University of Health Science, Elmalıkent, Adem Yavuz Cd., 34764, Ümraniye/İstanbul, Turkey.
(8)Department of Infectious Diseases and Clinical Microbiology, University of Health Science Ankara Research and Training Hospital, Ankara, Turkey.
(9)Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Research and Training Hospital, Istanbul, Turkey.
(10)Department of Infectious Diseases and Clinical Microbiology, Baskent University School of Medicine, Ankara, Turkey.
(11)University of Health Science Kütahya Evliya Çelebi Research and Training Hospital, Kütahya, Turkey.
(12)Department of Infectious Diseases and Clinical Microbiology, Batman State Hospital, Batman, Turkey.
(13)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul University, Istanbul, Turkey.
(14)Department of Infectious Diseases and Clinical Microbiology, Afyonkarahisar University of Health Science, Afyon, Turkey.
(15)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara University, Ankara, Turkey.
(16)Department of Infectious Diseases and Clinical Microbiology, Afyonkarahisar State Hospital, Afyon, Turkey.
(17)Department of Infectious Diseases and Clinical Microbiology, Istinye University, Istanbul, Turkey.
(18)Department of Infectious Diseases and Clinical Microbiology School of Medicine, Hitit University, Corum, Turkey.
(19)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Erzincan Binali Yıldırım University, Erzincan, Turkey.
(20)University of Health Science Samsun Research and Training Hospital, Samsun, Turkey.
(21)School of Medicine Department of Infectious Diseases and Clinical Microbiology, Koc University, Istanbul, Turkey.
(22)School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Bozok University, Yozgat, Turkey.
(23)Department of Infectious Diseases and Clinical Microbiology, Florans Nightingale Hospital, Istanbul, Turkey.

Abstract

To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%.