Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry.


Jordan A(1), Stoy P(2), Sneddon HF(3).
Author information:
(1)GlaxoSmithKline Carbon Neutral Laboratory for Sustainable Chemistry, Jubilee Campus, University of Nottingham, 6 Triumph Road, Nottingham NG7 2GA, U.K.
(2)Drug Design and Selection, Platform and Technology Sciences, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
(3)GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.


Chlorinated solvents were once, and in many places are still, ubiquitous in chemistry laboratories. This review explores the properties that led to such widespread use, why there is now an increasing drive to minimize usage, and what alternatives are currently available.