Clinical and microbiological characterization of subclinical bacteriuria and sporadic bacterial cystitis in dogs with spontaneous hypercortisolism.

Machado L

Machado L(1), de Oliveira MC(2), Barbieri CR(2), Riboldi CI(2), Leotti VB(3), González FHD(4), Valle SF(4), Siqueira FM(4), Pöppl ÁG(5).
Author information:
(1)Veterinary Sciences Post-Graduation Program, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil.
(2)Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil.
(3)Department of Statistics, Mathematics and Statistics Institute, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9500, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil.
(4)Veterinary Sciences Post-Graduation Program, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil; Department of Veterinary Clinical Pathology, School of Veterinary Medicine, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil.
(5)Veterinary Sciences Post-Graduation Program, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil; Department of Animal Medicine, School of Veterinary Medicine, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, Rio Grande do Sul, CEP 91540-000, Brazil. Electronic address: [Email]

https://dx.doi.org/10.1016/j.cimid.2021.101624

Study's aims were to characterize subclinical bacteriuria (SB) and sporadic bacterial cystitis (SBC) in dogs with spontaneous hypercortisolism (HC). Prospective cross-sectional design divided patients as newly diagnosed (n = 27), poorly controlled (n  = 21), well controlled (n  = 34), and controls (n  = 19). Urine culture positive results were identified by MALDI-TOF and submitted to antibiogram. Escherichia coli was the most common microorganism (36%). The majority of positive cultures in HC were SB (12.2%). All 4.1% SBC cases were in well controlled HC cases. Bacteriuria correlated with low urine specific gravity and low lymphocyte count. HC degree of control correlated with leukocyturia. SB/SBC cases were treated based in antimicrobial susceptibility leading to microbiological cure in 75% of HC cases. Persistent infections occurred only in SB cases, all by E. coli which became more resistant. SB/SBC prevalence in canine HC is actually lower. Further evidence for current ISCAID guideline contraindication for SB treatment due to HC were provided.