Combined cerebral atrophy score in Huntington's disease based on atlas-based MRI volumetry: Sample size calculations for clinical trials.

Affiliation

Department of Neurology, University of Ulm, Germany. Electronic address: [Email]

Abstract

A volumetric MRI analysis of longitudinal regional cerebral atrophy in Huntington's disease (HD) was performed as a read-out of disease progression to calculate sample sizes for future clinical trials.

Keywords

Atlas-based volumetry,Clinical trial,Effect size,Huntington's disease,Longitudinal study,Multicenter study,Surrogate marker,

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