Comparison of hyperspectral imaging techniques for the elucidation of falsified medicines composition.

Affiliation

University of Liege (ULiege), CIRM, VibraSanté Hub, Department of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, CHU, B36, 4000 Liege, Belgium. Electronic address: [Email]

Abstract

Hyperspectral imaging has shown a high potential to analyze falsifications of solid pharmaceutical products since the last decade. Thanks to the non-destructive, ecological and non-invasive properties, it is a preferred technique for these kinds of applications. Moreover, thanks to the spectroscopic properties, it is possible to detect as well organic compounds as inorganic compounds in a single analysis. Therefore, we recommend using it as second-line laboratory analysis technique. Raman microscopy and Fourier Transform Infrared (FT-IR) microscopy are two interesting techniques that are complementary. In this study, the potential of the two hyperspectral imaging techniques is evaluated to elucidate the composition of falsified antimalarial tablets. Hyperspectral data are analyzed by Multivariate Curve Resolution-Alternating Least Square (MCR-ALS). The results obtained from this study show that Raman hyperspectral imaging seems to be more suited to detect low dosed compounds possibly due to a smallest sampling volume. It has been also possible to link formulations of falsified samples of two different brands.

Keywords

Antimalarial,FT-IR spectroscopy,Falsification,Hyperspectral imaging,Raman spectroscopy,

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