Confirmation of Ath26 locus on chromosome 17 and identification of Cyp4f13 as an atherosclerosis modifying gene.

Affiliation

Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, OH, 44122, USA. Electronic address: [Email]

Abstract

We previously demonstrated that Apoe-/- mice on DBA/2 vs. AKR genetic background have >10-fold larger atherosclerotic lesions. Prior quantitative trait locus mapping via strain intercrossing identified a region on chromosome 17, Ath26, as the strongest atherosclerosis-modifying locus. We aimed to confirm Ath26, identify candidate genes, and validate the candidate gene effects on atherosclerosis.

Keywords

Atherosclerosis,Cytochrome P-450 enzyme system,Inflammation,Leukotriene B4,