The present study aimed to enhance the biomethanation potential of mixed microalgae via cost effective surfactant coupled ultrasonic homogenization (SCUH). Mixed microalgae biomass was harvested using a coagulant (Alum) from a raceway pond. The harvested algal biomass was subjected to ultrasonic homogenization (UH) by varying the power from 100 to 180 W. A maximal soluble organic release of 2131 mg/L was achieved at an ultrasonic input energy (UIE) of 25200 kJ/kg TS. In order to enhance soluble organic release and to reduce energy spent, the optimized condition of ultrasonic pretreatment was coupled with varying sodium dodecyl sulphate (SDS) dosage. A higher solubilization of 30.5% was achieved at a UIE of 4200 kJ/kg SS with surfactant dosage of 0.02 g SDS/g SS for SCUH. SCUH showed higher methane production of 358 mL/g COD when compared to UH (185.9 mL/g COD), SCUH was economically feasible than UH.