Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing.


Mahmoud A(1)(2), Echabaane M(3), Omri K(4), Boudon J(2), Saviot L(2), Millot N(2), Chaabane RB(1).
Author information:
(1)Laboratory Interfaces and Advanced Materials
(LIMA), Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia.
(2)Laboratoire Interdisciplinaire Carnot de Bourgogne
(ICB), UMR 6303 CNRS, Université Bourgogne Franche-Comté, 9 av. A. Savary, BP 47870, 21078 Dijon, France.
(3)NANOMISENE Lab., LR16CRMN01, Centre for Research on Microelectronics and Nanotechnology CRMN of Technopark of Sousse, B.P. 334, Sahloul, 4034 Sousse, Tunisia.
(4)Laboratory of Physics of Materials and Nanomaterials Applied at Environment
(LaPhyMNE), Faculty of Sciences of Gabes, University of Gabes, 6029 Gabes, Tunisia.


Copper-doped zinc oxide nanoparticles (NPs) CuxZn1-xO (x = 0, 0.01, 0.02, 0.03, and 0.04) were synthesized via a sol-gel process and used as an active electrode material to fabricate a non-enzymatic electrochemical sensor for the detection of glucose. Their structure, composition, and chemical properties were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) and Raman spectroscopies, and zeta potential measurements. The electrochemical characterization of the sensors was studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Cu doping was shown to improve the electrocatalytic activity for the oxidation of glucose, which resulted from the accelerated electron transfer and greatly improved electrochemical conductivity. The experimental conditions for the detection of glucose were optimized: a linear dependence between the glucose concentration and current intensity was established in the range from 1 nM to 100 μM with a limit of detection of 0.7 nM. The proposed sensor exhibited high selectivity for glucose in the presence of various interfering species. The developed sensor was also successfully tested for the detection of glucose in human serum samples.