DNA methylation and histone post-translational modification stability in post-mortem brain tissue.

Affiliation

Department of Pathology, University of Manitoba, Room 401 Brodie Centre - 727 McDermot Avenue, Winnipeg, MB, R3E 3P5, Canada. [Email]

Abstract

Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mortem stability of the modifications.

Keywords

Autopsy,Cortex,DNA methylation,Epigenetics,Histone acetylation,Histone methylation,Human brain,Mouse brain,Pig brain,Post-mortem delay,