Decreased M1 macrophage polarization in dabigatran-treated Ldlr-deficient mice: Implications for atherosclerosis and adipose tissue inflammation.


Institute for Pharmacology and Clinical Pharmacology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany; Cardiovascular Research Institute Duesseldorf (CARID), University Hospital, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany. Electronic address: [Email]


The non-vitamin K oral anticoagulant dabigatran etexilate (dabigatran) is increasingly prescribed to patients with non-valvular atrial fibrillation and venous thromboembolism. Adipose tissue (AT) inflammation during obesity plays a crucial role in the development of insulin resistance, type II diabetes and atherogenesis. The aim of the present study was to investigate the effects of thrombin inhibition by dabigatran in a combined model of diet-induced obesity and atherosclerosis.


Atherosclerosis,Inflammation,Macrophage,Obesity,Thrombin inhibitor,

OUR Recent Articles