Patel V(1), Humbert-Vidan L(2), Thomas C(3), Sassoon I(4), McGurk M(5), Fenlon M(6), Urbano TG(2). Author information:
(1)Oral Surgery Department, Guy's & St Thomas' NHS Foundation Trust, Great Maze
Pond, London, SE1 9RT, UK.
(2)Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, London,
(3)Department of Medical Physics, Guy's and St Thomas' NHS Foundation Trust,
(4)Computer Science Department, Brunel University London, Uxbridge, Middlesex,
(5)Head and Neck Unit, Head & Neck Centre, UCL Division of Surgical
Interventional Sciences, 235 Euston Rd, Bloomsbury, London, NW1 2BU, UK.
(6)Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London,
OBJECTIVES: This observational study aims to determine individual dental doses in oropharyngeal cancer (OPC) patients managed by intensity modulated radiation treatment (IMRT). MATERIALS AND METHODS: OPC patients treated with IMRT had each tooth individually contoured on post-IMRT CT scans. The mean, maximum and minimum doses were calculated per tooth-based upon patient and tumor demographics (tumor size and nodal status). RESULTS: A total of 160 patients were included in this study. Escalating tumor size and nodal status led to an observed increase in Dmean doses to the dentition on the contralateral tumor side. A significant region in both jaws received >30 Gy in this tumor group. CONCLUSION: Tumor demographics were observed to influence RT doses to the dentition and need to be considered when providing a pre-RT dental assessment. The observed dose of >30 Gy in large spans of the dentition and jaws highlights future risk of dental deterioration and ORN with long term survival.
Having over 250 Research scholars worldwide and more than 400 articles online with open access.