School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Hangkonglu 13, Wuhan 430030, People's Republic of China. Electronic address: [Email]
Ten new diarylheptanoids (1-10), including five diarylether-type (1-5), three biaryl-type (6-8), and two linear type (9-10), along with eighteen known ones, were isolated from the fresh pericarps of Juglans hopeiensis Hu. Their structures were settled by integrated spectroscopic techniques, and their absolute configurations were determined by a combination of circular dichroism analysis, optical rotations, and NOESY experiments. Screening results showed that some isolated diarylheptanoids exhibited moderate neuroprotective effects on H2O2-induced or CoCl2-induced cellular damage in human neuroblastoma SH-SY5Y cells.