Gao YY(1)(2), Zhang CL(1), Dai L(1)(2), Han YF(1)(2), Ye S(1)(2). Author information:
(1)Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of
Molecular Recognition and Function, CAS Research/Education Center for Excellence
in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences,
Beijing 100190, China.
(2)University of Chinese Academy of Sciences, Beijing 100049, China.
Following the well-recognized dynamic kinetic resolution (DKR) of hemiaminals with α-hydrogen under lipase and chiral DMAP catalysis, the unprecedented DKR of hemiaminals without α-hydrogen was developed via N-heterocyclic carbene catalyzed O-acylation of 3-hydroxy-3-trifluoromethylbenzosultams. The racemic hemiaminals without α-hydrogen were effectively racemized and differentiated by chiral NHCs under basic conditions. The resulting esters were obtained in high yields with good to high enantioselectivities.
OUR JOURNALS
Having over 250 Research scholars worldwide and more than 400 articles online with open access.
