EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.

Affiliation

Jang M(1), Park R(1), Park YI(1), Cha YE(1), Yamamoto A(1), Lee JI(1), Park J(2).
Author information:
(1)Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
(2)Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea. Electronic address: [Email]

Abstract

COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.