Elaeagnus L gum polysaccharides alleviate the impairment of barrier function in the dry skin model mice.


Wang B(1), Tai M(2), Zhang K(1), Chen H(3), Gan X(2), Che B(2), Abudukelimu N(4), Wang G(4), Xin X(4), Lin L(5), Han P(5), Peng Y(1), Du Z(1), Aker Aisa H(4).
Author information:
(1)The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.
(China) Co. Ltd., Guangzhou, China.
(3)Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale, Paris Cedex 06, France.
(4)The Key Laboratory of Plant Resources and Chemistry of Arid Zone, China Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi, China.
(5)Foshan Conney Allan Biotechnology Co. Ltd, Foshan, China.


BACKGROUND: Dry skin is a common skin condition caused by reduction of water-holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing. AIMS: It remains necessary to investigate the effects of Elaeagnus L gum polysaccharides (EAP), which are prepared from gum of Elaeagnus angustifolia L. on the epidermal permeability barrier function and their possible underlying mechanisms. PATIENTS/METHODS: EAP were purified, analyzed, and tested on human keratinocyte cell line (HaCaT) and then on the skin in vivo to evaluate their antiinflammatory activities and their impacts on impaired skin barrier function. RESULTS: Histological analyses revealed that topical administration with EAP effectively attenuated dryness-like skin condition, including less percutaneous water loss rate, less infiltrate inflammation cells, and less epidermal thickening. Moreover, EAP inhibited the production of various inflammatory mediators and increased AQP-3, FLG, and LOR expression. CONCLUSION: Our results indicated that EAP enhances epidermal permeability barrier function, and they can be used as a promising adjuvant agent in skin care cosmetics and in treating some skin disorders characterized by cutaneous inflammation and abnormal barrier function.