Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Affiliation

Department of Bioscience, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. Electronic address: [Email]

Abstract

Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear.

Keywords

Asthma,IL-6 signaling,airway inflammation,eosinophils,epithelial integrity,exacerbation frequency,hierarchical clustering,lung epithelium,remodeling,transcriptomics,

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