Evaluating Ga-68 Peptide Conjugates for Targeting VPAC Receptors: Stability and Pharmacokinetics.

Affiliation

Departments of Radiology, Thomas Jefferson University, Philadelphia, PA, USA. [Email]

Abstract

In recent years, considerable progress has been made in the use of gallium-68 labeled receptor-specific peptides for imaging oncologic diseases. The objective was to examine the stability and pharmacokinetics of [68Ga]NODAGA and DOTA-peptide conjugate targeting VPAC [combined for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP)] receptors on tumor cells.

Keywords

Chelating agents,Gallium-68,Molecular imaging,Radiochemistry,Tumor imaging,

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