Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis.

Affiliation

Biomarker R&D Department, Shionogi & Co., Ltd., Osaka, Japan. Electronic address: [Email]

Abstract

Melanocortin 4 receptor-deficient (MC4R-KO) mice fed a high-fat diet (HFD) develop liver pathology similar to human nonalcoholic steatohepatitis (NASH). However, although liver histology and blood biochemistry have been reported, hepatic function has not been evaluated. In the present study, we evaluated hepatic function in MC4R-KO mice fed an HFD using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium‑ethoxybenzyl‑diethylenetriamine pentaacetic acid (Gd-EOB-DTPA).

Keywords

Dynamic contrast-enhanced-MRI,Gd-EOB-DTPA,High-fat diet,Melanocortin 4 receptor-deficient mice,NASH,

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