Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane.


Laboratory of Stem Cells, Institute of Cell Biology, College of Life Sciences, Zhejiang University, Zhejiang, 310058, Hangzhou, China. [Email]


Induced pluripotent stem cells (iPSCs) can generate epithelial stem cells (EpSCs) as seed cells for skin substitutes to repair skin defects. Here, we investigated the effects of a human acellular amniotic membrane (hAAM) combined with iPSC-derived CD200+/ITGA6+ EpSCs as a skin substitute on repairing skin defects in nude mice.


CD200+/ITGA6+ epithelial stem cells,Hair follicle,Induced pluripotent stem cells,Skin defect,