Germline genetic contribution to the immune landscape of cancer.

Affiliation

Sayaman RW(1), Saad M(2), Thorsson V(3), Hu D(4), Hendrickx W(5), Roelands J(6), Porta-Pardo E(7), Mokrab Y(8), Farshidfar F(9), Kirchhoff T(10), Sweis RF(11), Bathe OF(12), Heimann C(3), Campbell MJ(13), Stretch C(14), Huntsman S(4), Graff RE(15), Syed N(16), Radvanyi L(17), Shelley S(18), Wolf D(19), Marincola FM(20), Ceccarelli M(21), Galon J(22), Ziv E(23), Bedognetti D(24).
Author information:
(1)Department of Population Sciences, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA; Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA; Biological Sciences and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: [Email]
(2)Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar; Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
(3)Institute for Systems Biology, Seattle, WA 98109, USA.
(4)Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
(5)Research Branch, Sidra Medicine, PO Box 26999 Doha, Qatar; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
(6)Research Branch, Sidra Medicine, PO Box 26999 Doha, Qatar; Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
(7)Barcelona Supercomputing Center
(BSC); Josep Carreras Leukaemia Research Institute
(IJC), Badalona, 08034 Barcelona, Catalonia, Spain.
(8)Research Branch, Sidra Medicine, PO Box 26999 Doha, Qatar; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar; Weill Cornell Medicine, Doha, Qatar.
(9)Department of Oncology, University of Calgary, Alberta AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, Calgary, Alberta AB T2N 4N1, Canada; Department of Biomedical Data Science and Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
(10)Perlmutter Cancer Center, New York University School of Medicine, New York University Langone Health, New York, NY 10016, USA.
(11)Department of Medicine, Section of Hematology/Oncology, Committee on Clinical Pharmacology and Pharmacogenomics, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.
(12)Department of Oncology, University of Calgary, Alberta AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, Calgary, Alberta AB T2N 4N1, Canada; Department of Surgery, University of Calgary, Calgary, Alberta AB T2N 4N1, Canada.
(13)Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
(14)Department of Oncology, University of Calgary, Alberta AB T2N 4N1, Canada; Arnie Charbonneau Cancer Institute, Calgary, Alberta AB T2N 4N1, Canada.
(15)Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA.
(16)Research Branch, Sidra Medicine, PO Box 26999 Doha, Qatar; Department of Science and Technology, University of Sannio, 82100 Benevento, Italy.
(17)Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
(18)Department of Research and Development, Leukemia Therapeutics, LLC, Hull, MA 02045, USA.
(19)Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
(20)Refuge Biotechnologies Inc., Menlo Park, CA 94025, USA.
(21)Department of Electrical Engineering and Information Technology, University of Naples "Federico II," 80128 Naples, Italy; Istituto di Ricerche Genetiche "G. Salvatore," Biogem s.c.ar.l., 83031 Ariano Irpino, Italy.
(22)INSERM, Laboratory of Integrative Cancer Immunology, Equipe Labellisée Ligue Contre Le Cancer, Centre de Recherche de Cordeliers, Université de Paris, Sorbonne Université, Paris, France.
(23)Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: [Email]
(24)Research Branch, Sidra Medicine, PO Box 26999 Doha, Qatar; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar; Department of Internal Medicine and Medical Specialties
(Di.M.I.), University of Genoa, 16132 Genoa, Italy. Electronic address: [Email]

Abstract

Comment in Immunity. 2021 Feb 9;54(2):199-201.