Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein.

Affiliation

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: [Email]

Abstract

The essential bacteriophage T7-encoded single-stranded DNA binding protein is the nexus of T7 DNA metabolism. Multiple layers of macromolecular interactions mediate its function in replication, recombination, repair, and the maturation of viral genomes. In addition to binding ssDNA, the protein binds to DNA polymerase and DNA helicase, regulating their activities. The protein displays potent homologous DNA annealing activity, underscoring its role in recombination.

Keywords

Bacteriophage T7,DNA replication annealing,Homologous,Recombination,Single-stranded DNA binding protein,

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