GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis.


Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: [Email]


Twin studies have demonstrated that both genetic and environmental factors influence risk for posttraumatic stress disorder (PTSD), and there is some evidence supporting the interplay of genes and environment (GxE). Many GxE studies within the PTSD literature have focused on genes implicated in the stress response system, such as FK506 binding protein 51 (FKBP5). Given inconsistencies across GxE literature as a whole, a meta-analysis to synthesize results is warranted.


Alcohol,FKBP5,GxE,Posttraumatic stress,Trauma,