Hollow Tobacco Mosaic Virus Coat Protein Assisted Self-Assembly of One-Dimensional Nanoarchitectures.


Zhang J(1)(2), Kankala RK(1)(2), Ma J(1)(2), Zhou Y(3), Wang SB(1)(2), Chen AZ(1)(2).
Author information:
(1)Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.
(2)Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, P. R. China.
(3)CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, P. R. China.


Herein, an efficient strategy to fabricate well-organized one-dimensional (1D) inorganic nanostructures is demonstrated by utilizing the hollow tobacco mosaic virus coat protein (TMVCP) as a restrictive template. Considering the advantages of the unique hollow structure and the dynamic self-assembly attribute of TMVCP, foreign nano-objects are successfully encapsulated and conveniently assembled into highly organized 1D chainlike structures in the cavity of the TMVCP multimer (TMV disk). Different kinds of functional nanoparticles, such as gold nanoparticles (AuNPs) and silver sulfide quantum dots (Ag2S QDs), are used to demonstrate the successful construction of ordered 1D nanochains in high yields. Notably, binary nanochains of such different kinds of nanoparticles are also constructed through co-assembling the TMV disk-coated AuNPs and Ag2S QDs. Further, the TMV-assisted AuNP nanochains are grown into the 1D nanowires through in situ Au deposition owing to the spatial confinement of the TMVCP cavity. Together, our findings indicate that the TMV-assisted self-assembly approach, resulting in higher yields and better controllability over the other reported studies based on directly mineralizing the metal architectures in the TMV nanorods, provides enormous potential toward the fabrication of highly complex hybrid-metal nanostructures.