Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2.

Affiliation

Department of Emergency, Xiangya Hospital of Central South University, Changsha 410008, PR China. Electronic address: [Email]

Abstract

Hydrogen is received as an inert gas that thought to be non-functional in vivo previously. Recently, emerging evidences showed that in ischemia/reperfusion (IR) condition, hydrogen reduced cellular reactive oxygen species (ROS) production and ameliorated cell apoptosis. However, the underlying mechanism of hydrogen on IR-induced apoptosis remains elusive. Here we tried to unravel the mode of action of hydrogen with rat adrenal medulla cell line PC-12 in vitro.

Keywords

Mitochondrial apoptosis,OGD/RP,Saturated hydrogen-rich saline,VDAC1,