Tian B(#)(1), Cai D(#)(2), Li W(#)(3), Bu Q(3), Wang M(1), Ye G(3), Liu J(4), Wang Y(2), Gou L(2), Yi J(5), Zuo Z(6). Author information:
(1)Institute of Preventive Veterinary Medicine, Sichuan Agricultural University,
Chengdu, 611130, China.
(2)Department of Veterinary Clinical Sciences, College of Veterinary Medicine,
Sichuan Agricultural University, Chengdu, 611130, China.
(3)Ministry of agriculture "Veterinary medicine and veterinary technology"
Sichuan scientific experimental observation station, Sichuan Agricultural
University, Chengdu, 611130, China.
(4)College of Veterinary Medicine, Shandong Agricultural University, Tai'an,
271018, China.
(5)Sichuan Academy of Animal Science, Chengdu, 610066, China.
(6)Department of Veterinary Clinical Sciences, College of Veterinary Medicine,
Sichuan Agricultural University, Chengdu, 611130, China. [Email]
(#)Contributed equally
In 2019, diarrhea cases occurred on cattle farms in Qionglai and Guang'an, Sichuan Province. Two out of 20 (10%) serum and nasal swab samples were positive when tested using a bovine viral diarrhea virus (BVDV) antigen-capture ELISA kit. Two non-cytopathic strains of BVDV were isolated and named QL1903 and GA190608, respectively. The nucleotide sequences of the genomes of the two isolates were 89.52% identical. Phylogenetic analysis based on the 5'-UTR sequence revealed that the BVDV isolate QL1903 belonged to BVDV subtype 1b, whereas isolate GA190608 clustered with strains HN1814, EN-19, and BJ09_26 in a separate branch, which has tentatively been classified as a new genetic subtype, "1v".
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