Identification of 3q oncogene SEC62 as a marker for distant metastasis and poor clinical outcome in invasive ductal breast cancer.

Affiliation

Department of Obstetrics and Gynecology, University of Saarland, 66424, Homburg, Saar, Germany. [Email]

Abstract

In previous studies, we have shown that SEC62 has an essential function in cell migration, epithelial-to-mesenchymal transition, and endoplasmic reticulum stress tolerance of cancer cells. SEC62 expression correlated with distant and lymph node metastasis and poor outcome in different cancer entities. In this initial study, we investigated SEC62 expression and its possible role as a prognostic and predictive biomarker in breast cancer (BC).

Keywords

Biomarker,Breast cancer,Immunohistochemistry,Metastasis,Prognostic factor,SEC62,

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