Identification of Active Sarcoidosis Using Chitotriosidase and Angiotensin-Converting Enzyme.

Affiliation

State University of Rio de Janeiro, Boulevard 28 de Setembro, 77 - Vila Isabel, 2nd floor - Pulmonology Service, Rio de Janeiro, RJ, 20551-030, Brazil. [Email]

Abstract

Activity/remission differentiation is a great challenge in the follow-up and treatment of sarcoidosis patients. Angiotensin-converting enzyme (ACE) and high sensitivity C-reactive protein (hs-CRP) were proposed as sarcoidosis biomarkers. More recently, chitotriosidase (CHITO) has been described as a better alternative. This study has the aim to evaluate the association of CHITO activity, ACE, hs-CRP or a combination of these biomarkers and to construct a clinical algorithm to differentiate between sarcoidosis activity/remission status.

Keywords

Activity,Angiotensin-converting enzyme,Biomarkers,Chitotriosidase,Sarcoidosis,

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