In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line.

Affiliation

Université Clermont- Auvergne, Imagerie Moléculaire et Stratégies Théranostiques, Inserm U1240, Centre Jean Perrin, BP 184, F-63005, Clermont-Ferrand, France. Electronic address: [Email]

Abstract

Phthalic acid esters are widely used to improve the plasticity of PVC in medical devices (MD). The most famous plasticizer is DEHP, whose use in medical devices has been contested by the European authorities since 2008. Several alternative plasticizers are being considered to replace DEHP, such as DEHT, TOTM, DINP or DINCH, but they are also released from the PVC throughout their life cycle and are metabolized in the same way as DEHP.

Keywords

Cytotoxicity,DEHP-Alternative plasticizers,DINCH,DINP,Metabolite synthesis,

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