Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease.

Affiliation

Neurology Department, Centro Hospitalário e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal. Electronic address: [Email]

Abstract

Neurofibrillary tangles and tau protein, the neuropathological hallmarks of Alzheimer's disease (AD), have been identified in patients with epilepsy. Tau protein was also associated with the modulation of neuronal excitability in animal models of AD.

Keywords

Alzheimer,Biomarkers,CSF,Epilepsy,Seizure,Tau,

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