Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Affiliation

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; National Heart and Lung Institute, Imperial College London, London, UK; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. Electronic address: [Email]

Abstract

We studied the role of interleukin 11 (IL11) signaling in the pathogenesis of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, and mouse models of NASH.

Keywords

Acta2,Alanine Aminotransferase,Collagen,Fatty Liver,

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