Insights into active intragenic enhancers.


School of Data and Computer Science, Sun Yat-Sen University, Guangzhou 510006, China; Guangdong Province Key Laboratory of Big Data Analysis and Processing, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: [Email]


Enhancers can regulate gene transcription from afar. Many enhancers are located in genes. Although the regulatory roles of several individual intragenic enhancers have been elaborated, a genome-wide insight into intragenic enhancers remains to be elucidated. We found that active intragenic enhancers have a preference for being located in expressed genes. Unlike intergenic enhancers, active intragenic enhancers are enriched of H3K79me2 epigenetic signal, and depleted of variant histone H2A.Z. Moreover, eRNAs of active intragenic enhancers show lower degradation rates than those of the other enhancers. Our findings will have implications in understanding functions of intragenic enhancers.



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