Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies.


Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, 5th floor, 234 East 149th Street, Bronx, NY, 10451, USA. [Email]


Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins.


Insulin-like growth factor binding protein,Preterm premature rupture of membranes,Sera,Twins,