Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.

Affiliation

Department of Integrative Medicine and Neurobiology School of Basic Medical Sciences, Shanghai, China. Electronic address: [Email]

Abstract

Depression has recently been referred to as a neuroimmune disease because it is characterized by inflammatory changes in the cerebral cortex and hippocampus. Studies have demonstrated that microglial activation plays a crucial role in releasing inflammatory cytokines in the central nervous system (CNS), thereby contributing to depression, the mechanism underlying which remains unclear.

Keywords

Clomipramine,Depression,IL-1β,LPS,Microglia,NLRP3,

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