Knowledge-aware multi-center clinical dataset adaptation: Problem, method, and application.

Affiliation

Chu J(1), Chen J(1), Chen X(1), Dong W(2), Shi J(3), Huang Z(4).
Author information:
(1)College of Biomedical Engineering and Instrument Science, Zhejiang University, China.
(2)Department of Cardiology, Chinese PLA General Hospital, China.
(3)Department of Medical Innovation Research, Medical Big Data Center, Chinese PLA General Hospital, China.
(4)College of Biomedical Engineering and Instrument Science, Zhejiang University, China. Electronic address: [Email]

Abstract

Adaptable utilization of clinical data collected from multiple centers, prompted by the need to overcome the shifts between the dataset distributions, and exploit these different datasets for potential clinical applications, has received significant attention in recent years. In this study, we propose a novel approach to this task by infusing an external knowledge graph (KG) into multi-center clinical data mining. Specifically, we propose an adversarial learning model to capture shared patient feature representations from multi-center heterogeneous clinical datasets, and employ an external KG to enrich the semantics of the patient sample by providing both clinical center-specific and center-general knowledge features, which are trained with a graph convolutional autoencoder. We evaluate the proposed model on a real clinical dataset extracted from the general cardiology wards of a Chinese hospital and a well-known public clinical dataset (MIMIC III, pertaining to ICU clinical settings) for the task of predicting acute kidney injury in patients with heart failure. The achieved experimental results demonstrate the efficacy of our proposed model.