Limonoids and other triterpenoids from Entandrophragma angolense.

Affiliation

Youn I(1), Wu Z(2), Papa S(1), Burdette JE(1), Oyawaluja BO(3), Lee H(1), Che CT(4).
Author information:
(1)Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States.
(2)Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
(3)Department of Pharmaceutical Chemistry, University of Lagos, 100213, Lagos, Nigeria.
(4)Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States. Electronic address: [Email]

Abstract

Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC50 values ranging from 2.0-5.9 μM.