Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.


Department of Physiology, University of Regensburg, Regensburg, Germany; and [Email]


Transepithelial chloride- secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure.


ADPKD,TMEM16A,anoctamin 1,ferroptosis,lipid peroxidation,reactive oxygen species,

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