Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.

Affiliation

Department of Physiology, University of Regensburg, Regensburg, Germany; and [Email]

Abstract

Transepithelial chloride- secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure.

Keywords

ADPKD,TMEM16A,anoctamin 1,ferroptosis,lipid peroxidation,reactive oxygen species,

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